{
 "brief_date": "2026-10-20",
 "generated_at": "2026-10-20T07:50:01.222822+08:00",
 "window": {
  "from": "2026-10-17",
  "to": "2026-10-20"
 },
 "instructions": "这是小动物医学简报的原始素材包。只使用本文件条目生成简报：临床研究/指南与监管写中文要点、英文要点、来源与日期、证据级别、链接；疾病预警只写中文翻译+原文链接；不要编造，未提供的结论不要写。",
 "counts": {
  "clinical_research": 4,
  "guidelines_regulation": 4,
  "disease_alerts": 4
 },
 "categories": {
  "clinical_research": [
   {
    "id": "pmid:42050858",
    "source": "PubMed",
    "journal": "The Veterinary record",
    "date": "2026-10-17",
    "title": "Evaluation of thyroglobulin autoantibodies in dogs at the time of diagnosis of hypoadrenocorticism and during treatment.",
    "abstract": "Autoimmune thyroiditis (AIT) may occur more frequently in dogs with hypoadrenocorticism (HA) than previously recognised. The objective of this study was to determine the presence of thyroglobulin autoantibodies (TgAAs) in dogs with HA. Dogs were included if HA was confirmed by an adrenocorticotropic hormone stimulation test conducted between 2019 and 2023. Serum total thyroxine, thyrotropin and TgAA were analysed from samples taken before and during HA treatment. Thirty-seven dogs were enrolled, with nine dogs showing positive TgAA titres at enrolment. Following HA treatment, TgAA became undetectable in six dogs; two showed persistent positive TgAA results and one was lost to follow-up. Additionally, two dogs that were initially TgAA negative developed hypothyroidism during the follow-up period. The overall prevalence of concurrent HA and hypothyroidism after initiation of hormone replacement therapy was three of 30 among the dogs for which follow-up data were available. The retrospective nature of the study, small sample size and incomplete follow-up data for some patients limit the conclusions that can be drawn. Our findings demonstrate the concurrent occurrence of two different autoimmune diseases, AIT and HA, and show that the presence of TgAA can completely resolve with cortisol replacement therapy. Therefore, it is recommended to reassess thyroid function after initiating HA treatment to avoid unnecessary lifelong thyroxine supplementation.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42050858/",
    "doi": "10.1002/vetr.70622",
    "pmid": "42050858",
    "authors": [
     "Christin Emming",
     "Sina Strey",
     "Ina Leiter"
    ],
    "collected_by": "pubmed_core",
    "priority": 84
   },
   {
    "id": "pmid:41491344",
    "source": "PubMed",
    "journal": "The Veterinary record",
    "date": "2026-10-17",
    "title": "Transpalpebral exenteration in dogs: A retrospective study (2003‒2023).",
    "abstract": "Transpalpebral exenteration is indicated in cases of neoplasia, infection or severe trauma involving the globe and orbit. Limited peer-reviewed literature exists on the indications, complications and outcomes associated with this procedure in dogs. This retrospective study analysed medical records of 35 dogs undergoing transpalpebral exenteration at three UK veterinary referral centres between 2003 and 2023. The data included signalment, diagnostic findings, surgical details and postoperative complications. Kruskal‒Wallis and Fisher's exact tests were used to analyse relationships between clinical variables and complications. Orbital neoplasia was the most common indication (54.3%, 19/35), followed by orbital inflammatory disease (25.7%, 9/35), orbital cyst (11.4%, 4/35), orbital foreign body (5.7%, 2/35) and orbital pseudotumour (2.9%, 1/35). Immediate postoperative complications (21 days) complications occurred in 20% (7/35) and 5.7% (2/35) of cases, respectively. Six patients (17.1%) required additional treatment. No significant correlations were found between the independent variables and complication rates. This study is limited by its retrospective nature and the small sample size. Transpalpebral exenteration is a safe procedure with primarily minor postoperative complications that typically resolve without intervention.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41491344/",
    "doi": "10.1002/vetr.70219",
    "pmid": "41491344",
    "authors": [
     "Kayal Patel",
     "Rodrigo Pinheiro de Lacerda",
     "Samuela Mazzucchelli"
    ],
    "collected_by": "pubmed_core",
    "priority": 84
   },
   {
    "id": "pmid:41427741",
    "source": "PubMed",
    "journal": "The Veterinary record",
    "date": "2026-10-17",
    "title": "Sensory profile of cats with potential pain-related diabetic neuropathy.",
    "abstract": "Diabetes mellitus (DM) can cause peripheral neuropathy. This study aimed to evaluate sensory function by measuring the mechanical nociceptive thresholds (MNT) and diffuse noxious inhibitory control (DNIC) of cats with diabetes mellitus (DMcats). Eight cats with DM and 12 healthy controls were included in a prospective, randomised study. MNT were measured by applying pressure against the metatarsal pad (MNTbio). MNT were also measured using a mechanical actuator attached to one of the cat's pelvic limbs (MNTtop). The DNIC was assessed by comparing MNTtop before and after a conditioning stimulus. MNTbio of the controls were significantly lower (2.1 ± 0.7 N) than those of DMcats (3.6 ± 1.2 N). DNIC and MNTtop were not different between groups. This study had a small cohort of patients and an MNT cut-off to prevent injuries. DMcats showed hypoalgesia and loss of sensory function. This study could not differentiate DNIC between healthy and those with DM.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/41427741/",
    "doi": "10.1002/vetr.70227",
    "pmid": "41427741",
    "authors": [
     "Hélène L M Ruel",
     "Vanessa Bruneau",
     "Berenice Conversy"
    ],
    "collected_by": "pubmed_core",
    "priority": 84
   },
   {
    "id": "pmid:42893846",
    "source": "PubMed",
    "journal": "Veterinary and comparative oncology",
    "date": "2026-10-18",
    "title": "Doxorubicin-induced Cardiotoxicity in Dogs: A Narrative Review.",
    "abstract": "Doxorubicin, an anthracycline widely used in both human and veterinary oncology, is highly effective against a variety of malignancies in dogs, including lymphomas, sarcomas and carcinomas. Despite its efficacy, doxorubicin exposure can be associated with cardiotoxicity, which may present acutely or chronically, potentially leading to severe cardiac arrhythmia and congestive heart failure. Mechanisms underlying cardiotoxicity are multifactorial, including oxidative stress, mitochondrial dysfunction, DNA damage via topoisomerase IIβ, inflammation and dysregulated cell death pathways such as apoptosis, pyroptosis and ferroptosis. In dogs, known risk factors include higher cumulative dose, breed predisposition to idiopathic dilated cardiomyopathy, and higher body weight. Cardiac biomarkers, electrocardiography, echocardiography and other advanced imaging techniques have been employed to detect cardiac changes that can be seen also in the absence of clinical signs. However, current evidence is predominantly derived from experimental and retrospective research, highlighting the need for large prospective clinical studies to strengthen recommendations for monitoring and prevention. A deeper understanding of doxorubicin-induced cardiotoxicity in dogs is needed to identify factors influencing individual susceptibility, clarify the progression from subclinical damage to clinical cardiac dysfunction, and guide future research. Emerging approaches, including advanced echocardiography, microRNAs, proteomic biomarkers and pharmacokinetic modelling, may help improve early detection and g",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42893846/",
    "doi": "10.1111/vco.70124",
    "pmid": "42893846",
    "authors": [
     "Supita Sunpongsri",
     "Tom Roos",
     "Ronette Gerhing"
    ],
    "collected_by": "pubmed_core",
    "priority": 71
   }
  ],
  "guidelines_regulation": [
   {
    "id": "fr:2026-21084",
    "source": "Federal Register / FDA",
    "journal": "Federal Register (Notice)",
    "date": "2026-10-15",
    "title": "Authorization of Emergency Use for Four Animal Drugs for the Prevention and Treatment of New World Screwworm; Availability",
    "abstract": "The Food and Drug Administration (FDA or the Agency) is announcing the issuance of four Emergency Use Authorizations (EUA or Authorization) under the Federal Food, Drug, and Cosmetic Act (FD&C Act) for new animal products. FDA has issued one EUA for an animal product as requested by Elanco US Inc. for application on or around wounds for the prevention of infestations caused by New World screwworm (Cochliomyia hominivorax; NWS) larvae (myiasis) in sheep, cattle, goats, swine, camelids, and the following captive and captured wildlife species: cervids, American bison, bighorn sheep, and Sonoran pronghorn. FDA has issued one EUA for an animal product as requested by Zoetis Inc. for the treatment of infestations caused by NWS (myiasis) in dogs and puppies. FDA has issued one EUA for an animal product as requested by Bimeda Animal Health Ltd. for the prevention of infestations caused by NWS (myiasis) in cattle. FDA has issued one EUA for an animal product as requested by Sergeant's Pet Care Products LLC for the treatment and prevention of infestations caused by NWS (myiasis) in dogs, puppies, cats and kittens 2 pounds of body weight or greater and 4 weeks of age and older. The Authorizations contain, among other things, conditions on the emergency use of the authorized products. The Authorizations follow the August 18, 2025, determination by the Secretary of Health and Human Services (HHS) that there is a significant potential for a public health emergency that has a significant potential to affect national security or the health and security of U.S. citizens living abroad and th",
    "url": "https://www.federalregister.gov/documents/2026/10/15/2026-21084/authorization-of-emergency-use-for-four-animal-drugs-for-the-prevention-and-treatment-of-new-world",
    "doi": null,
    "pmid": null,
    "document_number": "2026-21084",
    "collected_by": "federal_register",
    "priority": 0,
    "category_hint": "regulation"
   },
   {
    "id": "dvm360:https://www.dvm360.com/view/recover-first-aid-guidelines-give-veterinary-teams-a-playbook-for-coaching-clients",
    "source": "dvm360",
    "journal": "dvm360",
    "date": "2026-10-15",
    "title": "RECOVER first aid guidelines give veterinary teams a playbook for coaching clients",
    "abstract": "New guidelines from RECOVER are written for veterinary teams to teach owners, handlers, and other caregivers what to do in the minutes before a pet reaches the clinic.",
    "url": "https://www.dvm360.com/view/recover-first-aid-guidelines-give-veterinary-teams-a-playbook-for-coaching-clients",
    "doi": null,
    "pmid": null,
    "category_hint": "media_guideline",
    "collected_by": "dvm360",
    "priority": 0
   },
   {
    "id": "feed:WSAVA:https://wsava.org/updates/advancing-dental-care-worldwide-our-updated-global-dental-guidelines-are-here/",
    "source": "WSAVA RSS",
    "journal": "WSAVA",
    "date": "2026-09-24",
    "title": "Advancing Dental Care Worldwide: Our Updated Global Dental Guidelines Are Here",
    "abstract": "Our updated 2026 Global Dental Guidelines are now available, providing veterinary professionals worldwide with practical, evidence-based guidance to support the prevention, diagnosis and treatment of oral and dental disease in companion animals.",
    "url": "https://wsava.org/updates/advancing-dental-care-worldwide-our-updated-global-dental-guidelines-are-here/",
    "doi": null,
    "pmid": null,
    "category_hint": "guidelines",
    "collected_by": "feed_wsava",
    "priority": 0
   },
   {
    "id": "feed:WSAVA:https://wsava.org/updates/update-on-the-working-group-following-erratum-published-in-march-2025/",
    "source": "WSAVA RSS",
    "journal": "WSAVA",
    "date": "2026-08-29",
    "title": "Update on the Working Group following Erratum Published in March 2025",
    "abstract": "WSAVA has published an update on the Multidisciplinary Reproduction Control Working Group following the Erratum published in March 2025.",
    "url": "https://wsava.org/updates/update-on-the-working-group-following-erratum-published-in-march-2025/",
    "doi": null,
    "pmid": null,
    "category_hint": "guidelines",
    "collected_by": "feed_wsava",
    "priority": 0
   }
  ],
  "disease_alerts": [
   {
    "id": "pmid:42895611",
    "source": "PubMed",
    "journal": "Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]",
    "date": "2026-10-19",
    "title": "Molecular detection of Streptococcus Sp. isolated from the mouth and nose of humans and pets.",
    "abstract": "Several streptococcal species traverse the human-animal-environment interface, positioning them as particularly compelling subjects for One Health research. In contrast to strictly host-adapted pathogens, these species are observed to circulate among livestock, companion animals, aquaculture, and the broader environment, exhibiting demonstrable transmission to human populations. In this study, 200 swabs were collected from humans and animals (100 nasal and oral swabs were tested bacteriologically from individuals with respiratory infections and gastrointestinal illnesses of all genders and ages. 100 swabs were collected from pets (dogs and cats) of both genders and various ages. Various respiratory symptoms were tested to isolate and characterize the bacterial causes of respiratory infections and to identify bacteria that can infect both humans and their pets. Finally, the results were confirmed by primary culture media, the Vitk 2 system, and 16 S rRNA. The results of bacterial isolation from the human nose showed the presence of six streptococcal isolates, classified into three types: S. thoraltensis (3, 50%), followed by S. anginosus (2, 33.33%), and finally S. alactolyticus (1, 16.66%). Moreover, the results from the human mouth showed the existence of 15 streptococcal isolates, divided into four types: S. salivarius (5, 33.33%), followed by S. thoraltensis (4, 26.66%), then S. alactolyticus and S. parasanguinis (3, 20%). At the same time, the results from the dog nose showed the presence of four streptococcal isolates, classified into three types: S. anginosus (2, 50%)",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42895611/",
    "doi": "10.1007/s42770-026-02101-9",
    "pmid": "42895611",
    "authors": [
     "Hassan F Mohammed",
     "Ibrahim M Kamal",
     "Ban S Al-Nasiry"
    ],
    "collected_by": "pubmed_alerts",
    "priority": 58
   },
   {
    "id": "gnews:https://news.google.com/rss/articles/CBMiZEFVX3lxTE1jWlU3aER6aExUaGViUkI5a09JZHE1VXV4UmhhWVRtUUJpblRWVXI3S0F2ZEdSMUJkOHB5b2ZLZ3lrdy05am1XQ3hVcVhkc0J3aGNscHBBdmhGbzJ3UWJ3WEk4d3Y?oc=",
    "source": "Google News",
    "journal": "Google News: H5N1 cat",
    "date": "2026-10-19",
    "title": "Cat Infectious Virus Alert - UExpress",
    "abstract": "Cat Infectious Virus Alert  UExpress",
    "url": "https://news.google.com/rss/articles/CBMiZEFVX3lxTE1jWlU3aER6aExUaGViUkI5a09JZHE1VXV4UmhhWVRtUUJpblRWVXI3S0F2ZEdSMUJkOHB5b2ZLZ3lrdy05am1XQ3hVcVhkc0J3aGNscHBBdmhGbzJ3UWJ3WEk4d3Y?oc=5",
    "doi": null,
    "pmid": null,
    "category_hint": "media_alert",
    "collected_by": "gnews",
    "priority": 0
   },
   {
    "id": "gnews:https://news.google.com/rss/articles/CBMiogFBVV95cUxPcF9fTGEyZmM4c01WQmtHX2stTDRNSzdMOUtuUDV3ekRuelBPbHE0UXAxZUlrSGFUSmNZTjdDaXk2RTdwQWViQ0VvcTRzc0I2M0lvOVNYb3BidF9JUnBHX2U1MklHS3Z",
    "source": "Google News",
    "journal": "Google News: dog parvovirus outbreak",
    "date": "2026-10-19",
    "title": "Deadly feline disease outbreak kills 20 cats in Rivière-du-Loup, Que. - CBC",
    "abstract": "Deadly feline disease outbreak kills 20 cats in Rivière-du-Loup, Que.  CBC",
    "url": "https://news.google.com/rss/articles/CBMiogFBVV95cUxPcF9fTGEyZmM4c01WQmtHX2stTDRNSzdMOUtuUDV3ekRuelBPbHE0UXAxZUlrSGFUSmNZTjdDaXk2RTdwQWViQ0VvcTRzc0I2M0lvOVNYb3BidF9JUnBHX2U1MklHS3ZhZEVYcXhwSXRhbEIybU9WdmFOYW9sMDlHQjVYc1VDeTlrTHdmQzhBTERzRThlVEpWMVNVTFFRMUNoZ0E?oc=5",
    "doi": null,
    "pmid": null,
    "category_hint": "media_alert",
    "collected_by": "gnews",
    "priority": 0
   },
   {
    "id": "dvm360:https://www.dvm360.com/view/dvm360-live-returns-with-a-doj-pet-food-lawsuit-screwworm-surveillance-and-more",
    "source": "dvm360",
    "journal": "dvm360",
    "date": "2026-10-16",
    "title": "dvm360 Live! returns with a DOJ pet food lawsuit, screwworm surveillance, and more",
    "abstract": "Adam Christman, DVM, MBA, returns as host for season 3, featuring a roundup of recent veterinary news and an appearance by guest Steve Mehler, DVM, DACVS.",
    "url": "https://www.dvm360.com/view/dvm360-live-returns-with-a-doj-pet-food-lawsuit-screwworm-surveillance-and-more",
    "doi": null,
    "pmid": null,
    "category_hint": "media_alert",
    "collected_by": "dvm360",
    "priority": 0
   }
  ]
 },
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   "count": 7
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  "pubmed_alerts": {
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   "ok": true,
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 }
}