{
 "brief_date": "2026-10-23",
 "generated_at": "2026-10-23T07:50:01.359800+08:00",
 "window": {
  "from": "2026-10-20",
  "to": "2026-10-23"
 },
 "instructions": "这是小动物医学简报的原始素材包。只使用本文件条目生成简报：临床研究/指南与监管写中文要点、英文要点、来源与日期、证据级别、链接；疾病预警只写中文翻译+原文链接；不要编造，未提供的结论不要写。",
 "counts": {
  "clinical_research": 1,
  "guidelines_regulation": 5,
  "disease_alerts": 8
 },
 "categories": {
  "clinical_research": [
   {
    "id": "pmid:42901292",
    "source": "PubMed",
    "journal": "Acta tropica",
    "date": "2026-10-20",
    "title": "Clinical and dermatological findings associated with Leishmania spp. test-positivity in shelter dogs of Kastamonu, Black Sea region of Türkiye: an exploratory cross-sectional study.",
    "abstract": "Canine leishmaniosis (CanL) has a broad clinical spectrum, with cutaneous abnormalities among its most frequent manifestations. We characterised clinical and dermatological findings in 200 stray dogs admitted to the municipal shelter of Kastamonu, Türkiye, and explored associations with Leishmania test positivity, lymphadenopathy, age, sex, sampling month and geographic origin. Blood samples were examined by thin blood-smear microscopy and a lateral-flow serological rapid test. Nine dogs (4.5%) met the study's combined definition of test positivity. Above-normal body temperature, lymph-node abnormalities and skin abnormalities were recorded in 33.5%, 16% and 15% of dogs, respectively. Abnormal skin status was significantly associated with test positivity (microscopy p<0.001; combined positivity p=0.031, OR 5.08, 95% CI 1.28-20.15; Fisher exact tests), consistent with a rank-correlation analysis. All four microscopy-positive dogs had abnormal skin (4/30), whereas rapid/combined positivity occurred in 4/30 dogs with abnormal skin and 5/170 with healthy skin. Lymph-node status differed by sex in an exploratory Mann-Whitney analysis (U=4363.50; p=0.026). Skin-health ranks differed across recorded ages (Kruskal-Wallis χ²=31.797; df=10; p<0.001) and sampling months (χ²=13.541; df=5; p=0.019), but sparse older-age strata, uneven monthly sampling and an association between month and age limited inference. The data did not support a bimodal age distribution or an autumn-winter increase in skin abnormalities. Because diagnostic and lesion-specific confirmation were limited, these fin",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42901292/",
    "doi": "10.1016/j.actatropica.2026.108376",
    "pmid": "42901292",
    "authors": [
     "Erdi Civek",
     "Özcan Özkan"
    ],
    "collected_by": "pubmed_alerts",
    "priority": 54
   }
  ],
  "guidelines_regulation": [
   {
    "id": "fr:2026-21516",
    "source": "Federal Register / FDA",
    "journal": "Federal Register (Notice)",
    "date": "2026-10-21",
    "title": "Regulatory Considerations for Prescription Drug Use-Related Software; Guidance for Industry; Availability",
    "abstract": "The Food and Drug Administration (FDA or Agency) is announcing the availability of a final guidance for industry titled \"Regulatory Considerations for Prescription Drug Use-Related Software.\" This final guidance describes FDA's application of its drug labeling authorities to certain software outputs that are disseminated by or on behalf of a drug sponsor for use with a prescription drug product or a prescription drug-led, drug-device combination product that is assigned to the Center for Drug Evaluation and Research or the Center for Biologics Evaluation and Research as the lead center. This guidance finalizes the draft guidance of the same title issued on September 19, 2023.",
    "url": "https://www.federalregister.gov/documents/2026/10/21/2026-21516/regulatory-considerations-for-prescription-drug-use-related-software-guidance-for-industry",
    "doi": null,
    "pmid": null,
    "document_number": "2026-21516",
    "collected_by": "federal_register",
    "priority": 0,
    "category_hint": "regulation"
   },
   {
    "id": "fr:2026-21453",
    "source": "Federal Register / FDA",
    "journal": "Federal Register (Notice)",
    "date": "2026-10-20",
    "title": "New Dietary Ingredient (NDI) Notifications and Related Issues; Identity and Safety Information About the NDI: Guidance for Industry; Availability",
    "abstract": "The Food and Drug Administration (FDA or we) is announcing the availability of a final guidance for industry entitled \"New Dietary Ingredient (NDI) Notifications and Related Issues; Identity and Safety Information About the NDI: Guidance for Industry.\" The guidance focuses on frequently asked questions about the new dietary ingredient notification (NDIN) submissions. This guidance is intended to help provide recommendations to manufacturers and distributors of NDIs and dietary supplements containing an NDI regarding the identity and safety information that should be included in an NDIN.",
    "url": "https://www.federalregister.gov/documents/2026/10/20/2026-21453/new-dietary-ingredient-ndi-notifications-and-related-issues-identity-and-safety-information-about",
    "doi": null,
    "pmid": null,
    "document_number": "2026-21453",
    "collected_by": "federal_register",
    "priority": 0,
    "category_hint": "regulation"
   },
   {
    "id": "dvm360:https://www.dvm360.com/view/recover-first-aid-guidelines-give-veterinary-teams-a-playbook-for-coaching-clients",
    "source": "dvm360",
    "journal": "dvm360",
    "date": "2026-10-15",
    "title": "RECOVER first aid guidelines give veterinary teams a playbook for coaching clients",
    "abstract": "New guidelines from RECOVER are written for veterinary teams to teach owners, handlers, and other caregivers what to do in the minutes before a pet reaches the clinic.",
    "url": "https://www.dvm360.com/view/recover-first-aid-guidelines-give-veterinary-teams-a-playbook-for-coaching-clients",
    "doi": null,
    "pmid": null,
    "category_hint": "media_guideline",
    "collected_by": "dvm360",
    "priority": 0
   },
   {
    "id": "feed:WSAVA:https://wsava.org/updates/advancing-dental-care-worldwide-our-updated-global-dental-guidelines-are-here/",
    "source": "WSAVA RSS",
    "journal": "WSAVA",
    "date": "2026-09-24",
    "title": "Advancing Dental Care Worldwide: Our Updated Global Dental Guidelines Are Here",
    "abstract": "Our updated 2026 Global Dental Guidelines are now available, providing veterinary professionals worldwide with practical, evidence-based guidance to support the prevention, diagnosis and treatment of oral and dental disease in companion animals.",
    "url": "https://wsava.org/updates/advancing-dental-care-worldwide-our-updated-global-dental-guidelines-are-here/",
    "doi": null,
    "pmid": null,
    "category_hint": "guidelines",
    "collected_by": "feed_wsava",
    "priority": 0
   },
   {
    "id": "feed:WSAVA:https://wsava.org/updates/update-on-the-working-group-following-erratum-published-in-march-2025/",
    "source": "WSAVA RSS",
    "journal": "WSAVA",
    "date": "2026-08-29",
    "title": "Update on the Working Group following Erratum Published in March 2025",
    "abstract": "WSAVA has published an update on the Multidisciplinary Reproduction Control Working Group following the Erratum published in March 2025.",
    "url": "https://wsava.org/updates/update-on-the-working-group-following-erratum-published-in-march-2025/",
    "doi": null,
    "pmid": null,
    "category_hint": "guidelines",
    "collected_by": "feed_wsava",
    "priority": 0
   }
  ],
  "disease_alerts": [
   {
    "id": "pmid:42648813",
    "source": "PubMed",
    "journal": "Analytica chimica acta",
    "date": "2026-10-22",
    "title": "CRISPR/Cas12a-based dual intelligent sensors for home pet detection via personal glucose meters.",
    "abstract": "Against the backdrop of iterative upgrades in pet pathogen detection technology, rapid on-site testing (POCT) has become the core technology for on-site identification of deadly pet diseases. Based on the research and development of new materials, intelligent sensors with high sensitivity, fast response, and high design flexibility have demonstrated strong application value and have become an important development direction for the next-generation technology system in the field of pet pathogen detection. Herein, we report two advanced intelligent material-integrated biosensing platforms: a DNA hydrogel-encapsulated glucose amylase-based assay (RC-HGPGA) and a magnetic nanoparticles (MNPs)-based system where single-stranded DNA (ssDNA) serves as a molecular bridge to conjugate MNPs with invertase (RC-MBI). Both systems operate via a cascade reaction: recombinase polymerase amplification (RPA) of target nucleic acids first activates Cas12a nuclease, which then exerts trans-cleavage activity toward the biosensing elements. Subsequent enzymatic hydrolysis generates glucose, whose concentration is quantifiable using a commercial personal glucose meter (PGM). All experimental procedures were conducted at a constant temperature of 37 °C, eliminating the need for complex thermal cycling equipment. Our findings demonstrate that the RC-HGPGA and RC-MBI platforms achieve ultra-sensitive detection of feline panleukopenia virus (FPV) and canine distemper virus (CDV)-two clinically significant pet viruses-with limits of detection (LODs) as low as 10° copies/μL and 101 copies/μL, respecti",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42648813/",
    "doi": "10.1016/j.aca.2026.345935",
    "pmid": "42648813",
    "authors": [
     "Mengqi Zhao",
     "Qianmin Zhuang",
     "Xiaowen Wang"
    ],
    "collected_by": "pubmed_alerts",
    "priority": 58
   },
   {
    "id": "gnews:https://news.google.com/rss/articles/CBMihgFBVV95cUxNYjdFSjdJbEx5MUF6ZUtfd2hzcTYwTkZCdU5QVlJzQ25lWTd1QnZXa3VaRzQyU014cHJIXzlCSjVwUEZ2cW5lOWRuN0lOdUkyWjNKckNrNkQ5XzY3S2QzS09QX0F6R29",
    "source": "Google News",
    "journal": "Google News: new world screwworm dog",
    "date": "2026-10-23",
    "title": "Screwworm in Texas: How to keep pets safe - FOX 4 News Dallas-Fort Worth",
    "abstract": "Screwworm in Texas: How to keep pets safe&nbsp;&nbsp;FOX 4 News Dallas-Fort Worth",
    "url": "https://news.google.com/rss/articles/CBMihgFBVV95cUxNYjdFSjdJbEx5MUF6ZUtfd2hzcTYwTkZCdU5QVlJzQ25lWTd1QnZXa3VaRzQyU014cHJIXzlCSjVwUEZ2cW5lOWRuN0lOdUkyWjNKckNrNkQ5XzY3S2QzS09QX0F6R29RMkhPaVNtcUg4RFBKX01tTHlmLTBHTk1iM19LRl9kQdIBiwFBVV95cUxNS1NVNmdmeEEyaFROYzk5UGhGQThsVThra1BnWkoxS3Y1UHJqSW94dWE1NnpEaDVJTlo1bTVvRE9ZanZMNlhEa3RNM29LQldLZUVnbUNPdEdjLVREM01PeVRvdFRoOUlVaWUwcDEwbnVIY2tIdThPcW10ZVFYWkJqOTFKVEZTUl9CM3dz?oc=5",
    "doi": null,
    "pmid": null,
    "category_hint": "media_alert",
    "collected_by": "gnews",
    "priority": 0
   },
   {
    "id": "gnews:https://news.google.com/rss/articles/CBMitAFBVV95cUxOS1dsaW9HbWhiOFFjcDlUdFNsTUFjYk1qWDV6RWpVZGJaamU3cElGbERJanVCNUhrZGJtY2c4MFI3Wm53a3Q5TjYxYzI5OTRjZ2VmZjE0YXRfTGFCakhUNjZGWG1Hc3R",
    "source": "Google News",
    "journal": "Google News: dog parvovirus outbreak",
    "date": "2026-10-22",
    "title": "Vet urges more pet owners to get dogs vaccinated amid virus outbreak - Kent Online",
    "abstract": "Vet urges more pet owners to get dogs vaccinated amid virus outbreak&nbsp;&nbsp;Kent Online",
    "url": "https://news.google.com/rss/articles/CBMitAFBVV95cUxOS1dsaW9HbWhiOFFjcDlUdFNsTUFjYk1qWDV6RWpVZGJaamU3cElGbERJanVCNUhrZGJtY2c4MFI3Wm53a3Q5TjYxYzI5OTRjZ2VmZjE0YXRfTGFCakhUNjZGWG1Hc3RTc3AzX0lPYmpSNDNXbEFOMGFNRUtjUlJCNHFNeHV2NUFpTzZUSXBZQk9zMm5YeGIzenRnM3FxR0hid1lvd3lCSjdVRkFZX2hSUTBPSlk?oc=5",
    "doi": null,
    "pmid": null,
    "category_hint": "media_alert",
    "collected_by": "gnews",
    "priority": 0
   },
   {
    "id": "dvm360:https://www.dvm360.com/view/higher-concentration-cefovecin-approved-by-fda-for-certain-skin-infections-in-dogs",
    "source": "dvm360",
    "journal": "dvm360",
    "date": "2026-10-21",
    "title": "Higher-concentration cefovecin approved by FDA for certain skin infections in dogs",
    "abstract": "A new version of an injectable antibiotic, first approved in 2008, is approved only for dogs, as 2 of its inactive ingredients may be toxic to cats.",
    "url": "https://www.dvm360.com/view/higher-concentration-cefovecin-approved-by-fda-for-certain-skin-infections-in-dogs",
    "doi": null,
    "pmid": null,
    "category_hint": "media_alert",
    "collected_by": "dvm360",
    "priority": 0
   },
   {
    "id": "gnews:https://news.google.com/rss/articles/CBMi0wFBVV95cUxOelRjc0tQbTlRcDZIWi1tang4TC0td3psY2Y3RVJnekJKN0F3Vko2RldnZnJSSS1qQXVqQktJSkg3WkRMSTdEOHdOanRpbHRlYkxBUUlYYjVSblRXRktnWTV2MloxTHM",
    "source": "Google News",
    "journal": "Google News: dog parvovirus outbreak",
    "date": "2026-10-20",
    "title": "Outbreak of highly contagious canine virus detected in Perth - PerthNow",
    "abstract": "Outbreak of highly contagious canine virus detected in Perth&nbsp;&nbsp;PerthNow",
    "url": "https://news.google.com/rss/articles/CBMi0wFBVV95cUxOelRjc0tQbTlRcDZIWi1tang4TC0td3psY2Y3RVJnekJKN0F3Vko2RldnZnJSSS1qQXVqQktJSkg3WkRMSTdEOHdOanRpbHRlYkxBUUlYYjVSblRXRktnWTV2MloxTHMzZW1LQ0R2OE1tMEtEQVZQZ194QmpYb241Y2tKdGJkTi1PMm9RSG0xQzloTlZsZUx0eHRoQno0M1NFNUYtMjd6VDFLeXFMLTRfYlJCQjRYSXFLaHE2SkpQQ294REFDa0dFTm5VczlweVlpVUcw?oc=5",
    "doi": null,
    "pmid": null,
    "category_hint": "media_alert",
    "collected_by": "gnews",
    "priority": 0
   },
   {
    "id": "gnews:https://news.google.com/rss/articles/CBMiZEFVX3lxTE1jWlU3aER6aExUaGViUkI5a09JZHE1VXV4UmhhWVRtUUJpblRWVXI3S0F2ZEdSMUJkOHB5b2ZLZ3lrdy05am1XQ3hVcVhkc0J3aGNscHBBdmhGbzJ3UWJ3WEk4d3Y?oc=",
    "source": "Google News",
    "journal": "Google News: H5N1 cat",
    "date": "2026-10-19",
    "title": "Cat Infectious Virus Alert - UExpress",
    "abstract": "Cat Infectious Virus Alert&nbsp;&nbsp;UExpress",
    "url": "https://news.google.com/rss/articles/CBMiZEFVX3lxTE1jWlU3aER6aExUaGViUkI5a09JZHE1VXV4UmhhWVRtUUJpblRWVXI3S0F2ZEdSMUJkOHB5b2ZLZ3lrdy05am1XQ3hVcVhkc0J3aGNscHBBdmhGbzJ3UWJ3WEk4d3Y?oc=5",
    "doi": null,
    "pmid": null,
    "category_hint": "media_alert",
    "collected_by": "gnews",
    "priority": 0
   },
   {
    "id": "gnews:https://news.google.com/rss/articles/CBMiogFBVV95cUxPcF9fTGEyZmM4c01WQmtHX2stTDRNSzdMOUtuUDV3ekRuelBPbHE0UXAxZUlrSGFUSmNZTjdDaXk2RTdwQWViQ0VvcTRzc0I2M0lvOVNYb3BidF9JUnBHX2U1MklHS3Z",
    "source": "Google News",
    "journal": "Google News: dog parvovirus outbreak",
    "date": "2026-10-19",
    "title": "Deadly feline disease outbreak kills 20 cats in Rivière-du-Loup, Que. - CBC",
    "abstract": "Deadly feline disease outbreak kills 20 cats in Rivière-du-Loup, Que.&nbsp;&nbsp;CBC",
    "url": "https://news.google.com/rss/articles/CBMiogFBVV95cUxPcF9fTGEyZmM4c01WQmtHX2stTDRNSzdMOUtuUDV3ekRuelBPbHE0UXAxZUlrSGFUSmNZTjdDaXk2RTdwQWViQ0VvcTRzc0I2M0lvOVNYb3BidF9JUnBHX2U1MklHS3ZhZEVYcXhwSXRhbEIybU9WdmFOYW9sMDlHQjVYc1VDeTlrTHdmQzhBTERzRThlVEpWMVNVTFFRMUNoZ0E?oc=5",
    "doi": null,
    "pmid": null,
    "category_hint": "media_alert",
    "collected_by": "gnews",
    "priority": 0
   },
   {
    "id": "dvm360:https://www.dvm360.com/view/dvm360-live-returns-with-a-doj-pet-food-lawsuit-screwworm-surveillance-and-more",
    "source": "dvm360",
    "journal": "dvm360",
    "date": "2026-10-16",
    "title": "dvm360 Live! returns with a DOJ pet food lawsuit, screwworm surveillance, and more",
    "abstract": "Adam Christman, DVM, MBA, returns as host for season 3, featuring a roundup of recent veterinary news and an appearance by guest Steve Mehler, DVM, DACVS.",
    "url": "https://www.dvm360.com/view/dvm360-live-returns-with-a-doj-pet-food-lawsuit-screwworm-surveillance-and-more",
    "doi": null,
    "pmid": null,
    "category_hint": "media_alert",
    "collected_by": "dvm360",
    "priority": 0
   }
  ]
 },
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  },
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   "ok": true,
   "count": 1
  },
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   "ok": true,
   "count": 3
  },
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   "ok": true,
   "count": 0
  },
  "gnews:cytauxzoonosis cat": {
   "ok": true,
   "count": 0
  },
  "gnews:screwworm New Mexico": {
   "ok": true,
   "count": 0
  }
 }
}