{
 "brief_date": "2026-10-24",
 "generated_at": "2026-10-24T07:50:01.804116+08:00",
 "window": {
  "from": "2026-10-21",
  "to": "2026-10-24"
 },
 "instructions": "这是小动物医学简报的原始素材包。只使用本文件条目生成简报：临床研究/指南与监管写中文要点、英文要点、来源与日期、证据级别、链接；疾病预警只写中文翻译+原文链接；不要编造，未提供的结论不要写。",
 "counts": {
  "clinical_research": 11,
  "guidelines_regulation": 5,
  "disease_alerts": 12
 },
 "categories": {
  "clinical_research": [
   {
    "id": "pmid:42906618",
    "source": "PubMed",
    "journal": "Journal of the American Veterinary Medical Association",
    "date": "2026-10-21",
    "title": "Intra-articular 2.5% polyacrylamide hydrogel provides sustained clinical improvement over 1 year in canine elbow osteoarthritis.",
    "abstract": "To evaluate the efficacy, safety, and tolerability of IA 2.5% injectable polyacrylamide hydrogel (iPAAG) in dogs with elbow osteoarthritis (OA). We hypothesized that treatment would improve pain and function, with minimal adverse events. This prospective single-site clinical study enrolled client-owned dogs from October 2023 to October 2024. Dogs with elbow OA confirmed by CT received unilateral or bilateral IA injections with 1 mL of 2.5% iPAAG. Assessments were conducted on day 0 (baseline) and at 2 weeks, 1 month, 3 months, 6 months, and 12 months after injection using the Canine Brief Pain Inventory (CBPI) Pain Severity Score, CBPI Pain Interference Score, modified Glasgow Composite Pain Scale, Numerical Rating Score, elbow goniometry, thoracic limb girth, and joint effusion. Complete blood count and serum biochemistry were performed at baseline and 3 months after injection. 18 dogs were treated; 16 completed the study. There were significant improvements in all measures between baseline and 3 to 12 months. The CBPI Pain Severity Score, CBPI Pain Interference Score, modified Glasgow Composite Pain Scale, Numerical Rating Score, elbow flexion, elbow extension, thoracic limb girth, and joint effusion had an overall effect size of 0.44, 0.53, 0.69, 0.63, 0.31, 0.64, 0.53, and 0.64, respectively. There were minimal, self-limiting adverse events and no clinically significant changes in blood work. 2.5% iPAAG appears to be well tolerated, safe, and effective for the IA treatment of canine elbow OA. Study limitations included a small sample size and lack of control group. Thes",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42906618/",
    "doi": "10.2460/javma.26.05.0435",
    "pmid": "42906618",
    "authors": [
     "Julie A Corral",
     "David Levine",
     "Jennifer A Barnhard"
    ],
    "collected_by": "pubmed_core",
    "priority": 104
   },
   {
    "id": "pmid:42908207",
    "source": "PubMed",
    "journal": "Journal of feline medicine and surgery",
    "date": "2026-10-21",
    "title": "EXPRESS: Experimental Evaluation of the Immunogenicity of Feline Erythrocyte Antigen 6 (FEA 6) in Transfusion-Naive FEA 6-Negative Cats.",
    "abstract": "ObjectivesFeline Erythrocyte Antigen 6 (FEA 6) is a newly identified red blood cell (RBC) antigen in cats discovered following an unintentional sensitization event, suggesting it can be immunogenic. Its ability to consistently induce alloimmunization remains unknown. This prospective study evaluated FEA 6 immunogenicity in transfusion-naive, FEA 6-negative cats by assessing anti-FEA 6 alloantibody production and plasma levels. A secondary objective was to bank polyclonal anti-FEA 6 antibodies.MethodsFifty-three cats underwent AB and extensive blood typing for FEAs 1-6, naturally occurring alloantibody (NOAb) screening, and compatibility testing to select donor-recipient pairs. FEA 6 prevalence was assessed in 82 type A cats. Two transfusion-naive, FEA 6-negative cats received FEA 6-positive, otherwise compatible RBC transfusions and were monitored for anti-FEA 6 alloantibody production by gel column agglutination. Repeat transfusions were performed if alloantibodies became undetectable. Agreement between recipient-derived and reference anti-FEA 6 alloantibodies was evaluated in 51 type A cats using kappa statistics.ResultsFEA 6 prevalence among type A cats was 75.6% (62/82); NOAb were detected in 10.3% of screened type A cats, but none were directed against FEA 6. Both recipients developed anti-FEA 6 alloantibodies. Recipient 1 responded after two sensitizations, whereas recipient 2 responded after a single transfusion. Both reached peak titers of 1:8, with alloantibodies detectable through days 372 and 200, respectively. Recipient-derived anti-FEA 6 alloantibodies showed s",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42908207/",
    "doi": "10.1177/1098612X261501941",
    "pmid": "42908207",
    "authors": [
     "Mohammad Yasan Bangash",
     "Marie-Claude Blais"
    ],
    "collected_by": "pubmed_core",
    "priority": 94
   },
   {
    "id": "pmid:42908201",
    "source": "PubMed",
    "journal": "Journal of feline medicine and surgery",
    "date": "2026-10-21",
    "title": "EXPRESS: Mineral Analysis of Feline Treats: Unrecognized Sources of Phosphorus and Calcium in the Management of Chronic Kidney Disease.",
    "abstract": "Dietary phosphorus restriction is a cornerstone of chronic kidney disease (CKD) management in cats. While therapeutic renal diets are formulated to limit phosphorus intake, treats also contribute to total dietary phosphorus and calcium intake. The objective of this study was to quantify the phosphorus and calcium content of some feline purée-style treats and evaluate their potential contribution to dietary mineral intake in cats with CKD. A convenience sample comprising four flavors of commercially available Inaba Churu purée treats and three flavors of Weurva low-phosphorus purée treats were analyzed. Phosphorus and calcium concentrations were quantified using inductively coupled plasma-optical emission spectrometry and reported descriptively as milligrams per sachet and milligrams per 100 kcal. Phosphorus content varied widely across products, ranging from 9 to 36 mg per sachet (64-600mg/100kcal). The evaluated Churu treats contained higher phosphorus concentrations (29-36 mg/ sachet) than the evaluated Weruva low-phosphorus formulations (9-10 mg/sachet). Calcium concentrations ranged from 0.14 to 4.06 mg per sachet (2.3-67.7 mg/100 kcal), with corresponding calcium-to-phosphorus (Ca:P) ratios ranging from 0.004 to 0.119. Phosphorus and calcium content, including Ca:P ratios, varied substantially among the products evaluated. These differences should be considered as part of the overall dietary management of cats with CKD, particularly when treats are administered routinely.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42908201/",
    "doi": "10.1177/1098612X261500321",
    "pmid": "42908201",
    "authors": [
     "Autumn Nourse Harris",
     "Tonya Harris",
     "Shelly Vaden"
    ],
    "collected_by": "pubmed_core",
    "priority": 94
   },
   {
    "id": "pmid:42908191",
    "source": "PubMed",
    "journal": "Journal of feline medicine and surgery",
    "date": "2026-10-21",
    "title": "EXPRESS: Assessment of an educational social media campaign on improving feline osteoarthritis pain awareness and knowledge among cat owners.",
    "abstract": "Objectives - Feline osteoarthritis (OA) is highly prevalent but often underdiagnosed, largely owing to owners' difficulty recognising subtle clinical signs. This study evaluated the effects of an evidence-based, peer-reviewed educational social media campaign on cat owners' knowledge and awareness of feline OA.Methods - A prospective, interventional study was conducted with a convenience sample of adult, non-veterinary cat owners recruited via social media. Participants completed a validated online survey assessing knowledge and attitudes about feline OA before and after viewing an evidence based social media campaign (i.e., the intervention) covering 4 domains (introduction, clinical signs, diagnosis, management). Paired non parametric tests compared pre- and post-intervention total knowledge scores, individual knowledge items and Likert scale attitude items.Results - A total of 53 participants completed both surveys. Mean total knowledge scores increased from 19.9 ± 3.1 to 23.6 ± 2.8 (p < 0.001). Correct identification of OA as non-curable increased from 49.1% to 83% (p < 0.001), and the misconception that OA only affects senior cats decreased from 13.2% to 0% (p = 0.02). Recognition of key risk factors improved: neutering after 6 months of age (9.4% to 60.4%, p < 0.001) and outdoor access (28.3% to 73.6%, p < 0.001). Recognition of scratching posts as an option for environment changes increased from 24.5% to 60.3% (p <0.001). The owners' confidence in their ability to contribute to diagnosis increased (Hodges-Lehmann shift +0.99, p = 0.04), knowledge of environmental mod",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42908191/",
    "doi": "10.1177/1098612X261499904",
    "pmid": "42908191",
    "authors": [
     "Wing Sum Wong",
     "Helena Alcântara",
     "Syed S U H Bukhari"
    ],
    "collected_by": "pubmed_core",
    "priority": 94
   },
   {
    "id": "pmid:42906593",
    "source": "PubMed",
    "journal": "American journal of veterinary research",
    "date": "2026-10-21",
    "title": "Sugammadex at 2 mg/kg provides rapid and sustained reversal of moderate rocuronium-induced neuromuscular blockade in isoflurane-anesthetized dogs.",
    "abstract": "To investigate the efficacy of 2 mg/kg sugammadex in reversing moderate rocuronium-induced neuromuscular blockade (NMB) in dogs, focusing on recovery time and recurarization. In this prospective, nonrandomized, unblinded experimental study, 12 healthy adult mixed-breed dogs were evaluated before elective surgery and assigned to a control group (spontaneous recovery; n = 6) or a reversal group (2 mg/kg sugammadex; n = 6). Anesthesia was induced with propofol and maintained with isoflurane without premedication. Neuromuscular function was monitored using train-of-four (TOF) acceleromyography. Moderate NMB was defined as TOF count 1 to 3, and complete NMB recovery was defined as a normalized TOF ratio (TOFR; measured TOFR/baseline TOFR) ≥ 0.9. Rocuronium (0.6 mg/kg IV) was administered, followed in the reversal group by sugammadex (2 mg/kg IV) at first-twitch (T1) reappearance. Dogs in the reversal group were monitored for 60 minutes after complete NMB recovery. Recovery time was defined as T1 reappearance to normalized TOFR ≥ 0.9; recurarization was defined as a subsequent decrease in normalized TOFR to < 0.9 after complete NMB recovery. Recovery time was significantly shorter in the reversal group (median [range], 1.3 [0.8 to 3.0] minutes) than in the control group (18.6 [12.3 to 35.5] minutes). No recurarization was observed. Sugammadex at 2 mg/kg provided rapid reversal of moderate rocuronium-induced NMB in isoflurane-anesthetized dogs. No recurarization was observed during the 60-minute monitoring period after complete NMB recovery. Sugammadex at 2 mg/kg may be considered",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42906593/",
    "doi": "10.2460/ajvr.26.07.0288",
    "pmid": "42906593",
    "authors": [
     "Rai-Ning Chang",
     "Hsien-Chi Wang",
     "Chao-Chin Chang"
    ],
    "collected_by": "pubmed_core",
    "priority": 74
   },
   {
    "id": "pmid:42906589",
    "source": "PubMed",
    "journal": "American journal of veterinary research",
    "date": "2026-10-21",
    "title": "Acute postoperative hypophosphatemia is a potential sequela following hepatectomy in dogs.",
    "abstract": "To describe posthepatectomy hypophosphatemia in dogs and evaluate whether the extent of hepatectomy was associated with postoperative hypophosphatemia. This was a retrospective, observational study of dogs that underwent hepatectomy from January 1, 2019, through December 15, 2025, with serum phosphorus concentrations recorded preoperatively and within 72 hours postoperatively. Dogs with comorbidities or complications expected to influence serum phosphorus were excluded. Data included extent of hepatectomy (division/subdivisional) and change in serum phosphorus concentration (ΔP). Phosphorus and the proportions of dogs with recorded hypophosphatemia were compared between dogs undergoing division hepatectomy and subdivisional hepatectomy using the Mann-Whitney test and Fisher's exact test, respectively. 42 dogs were included (19 subdivisional, 23 division hepatectomy). Median ΔP was -0.8 mg/dL (range, -3.8 to 3.4). ΔP was greater in dogs with division hepatectomy (-0.9 mg/dL; range, -3.8 to 3.4) than subdivisional hepatectomy (-0.5 mg/dL; range, -1.7 to 1.2). Seven of 42 dogs (16.7%) developed postoperative hypophosphatemia at a median of 20 hours (range, 16 to 43); all dogs had undergone division hepatectomy (7 of 23 [30.4%]). Three dogs were treated with IV potassium phosphate. No dogs (0 of 19 [0%]) with subdivisional hepatectomy had recorded hypophosphatemia. Hypophosphatemia can arise in dogs after liver resection, primarily following division hepatectomy or greater. There was an overall decrease in phosphorus for both divisional and subdivisional hepatectomy groups. Rou",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42906589/",
    "doi": "10.2460/ajvr.26.08.0332",
    "pmid": "42906589",
    "authors": [
     "Rachel E Bryant",
     "Owen T Skinner",
     "Michael Barchilon"
    ],
    "collected_by": "pubmed_core",
    "priority": 74
   },
   {
    "id": "pmid:42908490",
    "source": "PubMed",
    "journal": "Veterinary dermatology",
    "date": "2026-10-22",
    "title": "Efficacy and Safety of Allogeneic Mesenchymal Stromal Cells Versus Lokivetmab in Mild-To-Moderate Canine Atopic Dermatitis: A Single-Blind Randomised Study.",
    "abstract": "Canine atopic dermatitis (cAD) is a chronic allergic inflammatory skin disease that requires multimodal management. Allogeneic mesenchymal stromal cells (MSCs) have emerged as a potential therapeutic option. To evaluate the efficacy and safety of an investigational allogeneic adipose-derived MSC product (PK/CM-1) in dogs with cAD. Dogs with mild-to-moderate cAD were enrolled in a single-blind, randomised study and allocated in a 2:1 ratio either to an experimental group (receiving a single intravenous dose of PK/CM-1) or a control group (receiving three monthly subcutaneous doses of lokivetmab). Clinical outcomes were assessed using the Canine Atopic Dermatitis Extent and Severity Index, 4th iteration (CADESI-04) and pruritus Visual Analog Scale (PVAS) scores on Day (D)28 (primary end-point) and D7, D56 and D84. Safety assessments included haematological and biochemical analyses on D84, along with monitoring for adverse events. Thirty-two dogs were included. By D28, both CADESI-04 and PVAS scores had significantly decreased from baseline in both groups. No significant differences between groups were observed on D28 (p = 0.696 and p = 0.088, respectively). Clinical improvement was sustained up to D84. In the experimental group, CADESI-04 and PVAS scores were lower on D84 than on D28 (p = 0.0074 and p = 0.0015, respectively). Two adverse events (one severe and one mild) occurred during PK/CM-1 administration. No clinically significant haematological or biochemical abnormalities were observed. PK/CM-1 demonstrated comparable efficacy and safety to those of lokivetmab over a 3 ",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42908490/",
    "doi": "10.1111/vde.70136",
    "pmid": "42908490",
    "authors": [
     "Marta Pasikowska",
     "Jagoda Ciszewska-Ceran",
     "Agnieszka Cekiera"
    ],
    "collected_by": "pubmed_core",
    "priority": 71
   },
   {
    "id": "pmid:42906717",
    "source": "PubMed",
    "journal": "Topics in companion animal medicine",
    "date": "2026-10-21",
    "title": "Histomorphometric characterization of cardiac nodes in cattle, ponies, and cats.",
    "abstract": "The sinoatrial node (SAN) and atrioventricular node (AVN) are essential components of the cardiac conduction system and play a critical role in initiating and propagating the electrical impulse. To characterise these cardiac nodes across different species, we examined the hearts of ten cattle, ten cats, and five male ponies without evidence of cardiac disease using conventional histological and immunohistochemical techniques. Morphometric parameters of the nodes and their constituent cells were quantified at different magnifications. The SAN displayed an oval morphology in all species. Its diameter was 888.58 ± 6.36 μm in cats, 2143.17 ± 199.13 μm in ponies, and 2033.28 ± 939.44 μm in cattle. Mean nodal density was significantly higher in ponies than in cattle (p = 0.011). Pacemaker (P) cells of the AVN were significantly larger in ungulate species than in cats (p < 0.001). Heart bone (os cordis) was identified in all ten cattle hearts and in one cat heart, showing typical features of compact bone and bone marrow. Cartilaginous metaplasia was observed in all pony hearts and in 60% of cat hearts and was associated with reduced AVN size and cellularity in cats. These findings highlight important interspecies differences and contribute to the understanding of conduction system pathology in veterinary cardiology. The structural changes in the cardiac nodes in these species warrant more in-depth functional research, given the lack of functional cardiac assessment and the small sample size.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42906717/",
    "doi": "10.1016/j.tcam.2026.101107",
    "pmid": "42906717",
    "authors": [
     "Fabián Gómez-Torres",
     "Luis Ballesteros-Acuña",
     "Amparo Ruíz-Saurí"
    ],
    "collected_by": "pubmed_core",
    "priority": 54
   },
   {
    "id": "pmid:42906727",
    "source": "PubMed",
    "journal": "Microbial pathogenesis",
    "date": "2026-10-21",
    "title": "Mutidi-mensional pathogenicity characterization with emphasis on intestinal dysfunction mechanism of two circulating Chinese field strains of feline panleukopenia virus.",
    "abstract": "Feline panleukopenia virus (FPV) causes severe, highly contagious infectious diseases in domestic cats, yet the comprehensive pathogenic mechanisms of circulating field isolates remain incompletely elucidated. Here, two contemporary FPV field strains (F513 and F1105) were isolated and genetically characterized from clinical samples of FPV vaccinated diarrheic cats. In vivo pathogenicity assays demonstrated that both strains induced typical FPV clinical signs, with viral replication predominantly localized to the gastrointestinal tract and shedding primarily occurring via the fecal-oral route. Both isolates triggered robust, time-dependent humoral immune responses and progressive systemic oxidative stress in infected cats. Notably, FPV infection profoundly reshaped the feline intestinal microbiota, characterized by reduced microbial diversity, depleted beneficial commensals, and expanded potential pathogens. Histopathological analyses revealed that strain F513 induced more severe systemic necrotizing inflammatory lesions than F1105, accompanied by higher viral antigen loads in all examined tissues. Mechanistically, FPV infection significantly downregulated intestinal tight junction proteins (Claudin-1, Occludin, ZO-1), while upregulating myosin light chain kinase (MLCK) and the epithelial-mesenchymal transition (EMT) marker N-cadherin, thereby compromising intestinal epithelial barrier integrity. Collectively, these findings clarify the multi-dimensional pathogenic characteristics of FPV field strains and reveal a critical role for intestinal barrier dysfunction in FPV patho",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42906727/",
    "doi": "10.1016/j.micpath.2026.108892",
    "pmid": "42906727",
    "authors": [
     "Ang Tian",
     "Lihong Qi",
     "Junkun Wang"
    ],
    "collected_by": "pubmed_alerts",
    "priority": 54
   },
   {
    "id": "pmid:42905852",
    "source": "PubMed",
    "journal": "Science translational medicine",
    "date": "2026-10-21",
    "title": "A fluorescent choline kinase alpha inhibitor for intraoperative molecular imaging during resection of canine NSCLC tumors.",
    "abstract": "Choline kinase α (ChoKα) is a biomarker of lung cancer, is overexpressed in 60% of human pulmonary malignancies, and is associated with an aggressive phenotype and poor clinical outcome. Patients with lung cancer who undergo surgery have a recurrence rate of 30 to 50%, indicating a potential need for better tumor detection modalities. A near-infrared fluorescent ChoKα-targeting imaging agent, JAS239 (λex, λem: 745, 775 nanometers), was developed for intraoperative identification of tumors, their margins, and local metastases. In lung cancer cells, JAS239 inhibited phosphocholine production, reduced viability in a dose-dependent manner, and accumulated in the cytoplasm where ChoKα is active. JAS239 had favorable pharmacokinetics and pharmacodynamics for imaging metastatic lung lesions in mice. In situ and ex vivo fluorescence imaging of primary lung tumors in a canine clinical trial showed distinct tumor identification and margin delineation with a tumor-to-background ratio of 5.0 ± 0.6 and a contrast-to-variance ratio of 2.0 ± 0.2 at 0.5 milligram/kilogram. Fluorescence imaging identified a clinically significant event where an occult lesion was found after primary tumor resection. Fluorescence imaging also identified a close surgical margin, which prompted further investigation. Immunohistochemistry for ChoKα showed overexpression in canine lung tumors proportional to tumor fluorescence. Ex vivo human tumor painting demonstrated preferential JAS239 localization with a tumor-to-background ratio of 1.5 ± 0.1 and a contrast-to-variance ratio of 0.9 ± 0.1. These studies establ",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42905852/",
    "doi": "10.1126/scitranslmed.aea4947",
    "pmid": "42905852",
    "authors": [
     "Sofya A Osharovich",
     "David E Holt",
     "Michael C Hart"
    ],
    "collected_by": "pubmed_alerts",
    "priority": 54
   },
   {
    "id": "pmid:42905351",
    "source": "PubMed",
    "journal": "Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]",
    "date": "2026-10-21",
    "title": "Diagnostic performance of a loop-mediated isothermal amplification test for the diagnosis of human and cat sporotrichosis in two highly endemic areas in Brazil: insights from a real-world, field-based evaluation.",
    "abstract": "Sporotrichosis is a subacute to chronic mycosis of major public health relevance in endemic regions, affecting both humans and animals, particularly cats. Rapid and accessible diagnostic tools are urgently needed to improve case detection and disease surveillance. Thus, this study aimed to validate a previously described loop-mediated isothermal amplification (LAMP) assay for the diagnosis of sporotrichosis in clinical samples from humans and cats obtained in two highly endemic areas in Brazil. We conducted an observational study including human patients and cats with suspected sporotrichosis. Analytical sensitivity and specificity were initially assessed using reference strains of Sporothrix spp. The diagnostic performance of the LAMP assay was then evaluated in clinical samples at different incubation times and compared with culture results. Sensitivity, specificity, and additional diagnostic parameters were calculated separately for human and cat cases. The LAMP assay was able to detect the three major Sporothrix species associated with sporotrichosis, with higher analytical sensitivity for S. brasiliensis. However, when applied to human clinical samples, the assay showed limited sensitivity and specificity, particularly at earlier incubation times, resulting in poor overall diagnostic performance. In contrast, performance in cat samples was comparatively higher but still affected by false-positive and false-negative results. Despite promising analytical characteristics and previous success in experimental models, this LAMP protocol demonstrated limited diagnostic utilit",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42905351/",
    "doi": "10.1007/s42770-026-02121-5",
    "pmid": "42905351",
    "authors": [
     "Rodrigo Almeida-Paes",
     "Lívia Silveira Munhoz",
     "Susana Ruiz Mendoza"
    ],
    "collected_by": "pubmed_alerts",
    "priority": 54
   }
  ],
  "guidelines_regulation": [
   {
    "id": "fr:2026-21714",
    "source": "Federal Register / FDA",
    "journal": "Federal Register (Notice)",
    "date": "2026-10-23",
    "title": "Agency Information Collection Activities; Proposed Collection; Comment Request; Export Certificates for FDA Regulated Products",
    "abstract": "The Food and Drug Administration (FDA or Agency) is announcing an opportunity for public comment on the proposed collection of certain information by the Agency. Under the Paperwork Reduction Act of 1995 (PRA), Federal Agencies are required to publish notice in the Federal Register concerning each proposed collection of information, including each proposed extension of an existing collection of information, and to allow 60 days for public comment in response to the notice. This notice solicits comments on export certificates for FDA regulated products.",
    "url": "https://www.federalregister.gov/documents/2026/10/23/2026-21714/agency-information-collection-activities-proposed-collection-comment-request-export-certificates-for",
    "doi": null,
    "pmid": null,
    "document_number": "2026-21714",
    "collected_by": "federal_register",
    "priority": 0,
    "category_hint": "regulation"
   },
   {
    "id": "fr:2026-21516",
    "source": "Federal Register / FDA",
    "journal": "Federal Register (Notice)",
    "date": "2026-10-21",
    "title": "Regulatory Considerations for Prescription Drug Use-Related Software; Guidance for Industry; Availability",
    "abstract": "The Food and Drug Administration (FDA or Agency) is announcing the availability of a final guidance for industry titled \"Regulatory Considerations for Prescription Drug Use-Related Software.\" This final guidance describes FDA's application of its drug labeling authorities to certain software outputs that are disseminated by or on behalf of a drug sponsor for use with a prescription drug product or a prescription drug-led, drug-device combination product that is assigned to the Center for Drug Evaluation and Research or the Center for Biologics Evaluation and Research as the lead center. This guidance finalizes the draft guidance of the same title issued on September 19, 2023.",
    "url": "https://www.federalregister.gov/documents/2026/10/21/2026-21516/regulatory-considerations-for-prescription-drug-use-related-software-guidance-for-industry",
    "doi": null,
    "pmid": null,
    "document_number": "2026-21516",
    "collected_by": "federal_register",
    "priority": 0,
    "category_hint": "regulation"
   },
   {
    "id": "fr:2026-21453",
    "source": "Federal Register / FDA",
    "journal": "Federal Register (Notice)",
    "date": "2026-10-20",
    "title": "New Dietary Ingredient (NDI) Notifications and Related Issues; Identity and Safety Information About the NDI: Guidance for Industry; Availability",
    "abstract": "The Food and Drug Administration (FDA or we) is announcing the availability of a final guidance for industry entitled \"New Dietary Ingredient (NDI) Notifications and Related Issues; Identity and Safety Information About the NDI: Guidance for Industry.\" The guidance focuses on frequently asked questions about the new dietary ingredient notification (NDIN) submissions. This guidance is intended to help provide recommendations to manufacturers and distributors of NDIs and dietary supplements containing an NDI regarding the identity and safety information that should be included in an NDIN.",
    "url": "https://www.federalregister.gov/documents/2026/10/20/2026-21453/new-dietary-ingredient-ndi-notifications-and-related-issues-identity-and-safety-information-about",
    "doi": null,
    "pmid": null,
    "document_number": "2026-21453",
    "collected_by": "federal_register",
    "priority": 0,
    "category_hint": "regulation"
   },
   {
    "id": "feed:WSAVA:https://wsava.org/updates/advancing-dental-care-worldwide-our-updated-global-dental-guidelines-are-here/",
    "source": "WSAVA RSS",
    "journal": "WSAVA",
    "date": "2026-09-24",
    "title": "Advancing Dental Care Worldwide: Our Updated Global Dental Guidelines Are Here",
    "abstract": "Our updated 2026 Global Dental Guidelines are now available, providing veterinary professionals worldwide with practical, evidence-based guidance to support the prevention, diagnosis and treatment of oral and dental disease in companion animals.",
    "url": "https://wsava.org/updates/advancing-dental-care-worldwide-our-updated-global-dental-guidelines-are-here/",
    "doi": null,
    "pmid": null,
    "category_hint": "guidelines",
    "collected_by": "feed_wsava",
    "priority": 0
   },
   {
    "id": "feed:WSAVA:https://wsava.org/updates/update-on-the-working-group-following-erratum-published-in-march-2025/",
    "source": "WSAVA RSS",
    "journal": "WSAVA",
    "date": "2026-08-29",
    "title": "Update on the Working Group following Erratum Published in March 2025",
    "abstract": "WSAVA has published an update on the Multidisciplinary Reproduction Control Working Group following the Erratum published in March 2025.",
    "url": "https://wsava.org/updates/update-on-the-working-group-following-erratum-published-in-march-2025/",
    "doi": null,
    "pmid": null,
    "category_hint": "guidelines",
    "collected_by": "feed_wsava",
    "priority": 0
   }
  ],
  "disease_alerts": [
   {
    "id": "pmid:42911314",
    "source": "PubMed",
    "journal": "Veterinary research communications",
    "date": "2026-10-22",
    "title": "Serological response to field rabies vaccination in owned dogs in the immune belt of Peninsular Malaysia.",
    "abstract": "Rabies vaccination is conducted along the northern border of Peninsular Malaysia, but paired field serological data are limited. We analysed routine programme data from 154 owned dogs sampled immediately before vaccination and 30-83 days later (median, 43 days). Rabies virus-neutralising antibody levels were measured using the fluorescent antibody virus neutralisation test. Paired levels in IU/mL were compared using the Wilcoxon signed-rank test, and benchmark proportions were compared using the exact McNemar test. The proportion with levels ≥ 0.5 IU/mL increased from 72.7% (112/154; 95% confidence interval [CI], 65.2-79.1%) to 98.1% (151/154; 95% CI, 94.4-99.3%; p < 0.001). Three dogs remained below the benchmark. Median levels increased from 1.98 IU/mL (interquartile range [IQR], 0.38-5.92) to 13.5 IU/mL (IQR, 4.5-13.5); the median paired increase was 5.45 IU/mL (bootstrap 95% CI, 3.31-7.25; p < 0.001). Levels increased in 128 dogs, were unchanged in 19 and decreased in seven. Eighty follow-up values equalled the dataset maximum of 13.5 IU/mL, suggesting possible upper-end censoring. Vaccination history identified 99 previously vaccinated dogs and seven recorded as receiving their first vaccination, limiting comparison of these groups. Nearly all dogs retained at follow-up met the serological benchmark. Convenience sampling, incomplete follow-up and uncertain measurement limits restrict inference to this cohort and preclude estimates of population immunity or clinical effectiveness.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42911314/",
    "doi": "10.1007/s11259-026-11584-8",
    "pmid": "42911314",
    "authors": [
     "Muhamad Syamsul Naim Noorazmi",
     "Ahmad Fikri Ahmad Yunus",
     "Farid Zamani Che Rose"
    ],
    "collected_by": "pubmed_alerts",
    "priority": 56
   },
   {
    "id": "pmid:42648813",
    "source": "PubMed",
    "journal": "Analytica chimica acta",
    "date": "2026-10-22",
    "title": "CRISPR/Cas12a-based dual intelligent sensors for home pet detection via personal glucose meters.",
    "abstract": "Against the backdrop of iterative upgrades in pet pathogen detection technology, rapid on-site testing (POCT) has become the core technology for on-site identification of deadly pet diseases. Based on the research and development of new materials, intelligent sensors with high sensitivity, fast response, and high design flexibility have demonstrated strong application value and have become an important development direction for the next-generation technology system in the field of pet pathogen detection. Herein, we report two advanced intelligent material-integrated biosensing platforms: a DNA hydrogel-encapsulated glucose amylase-based assay (RC-HGPGA) and a magnetic nanoparticles (MNPs)-based system where single-stranded DNA (ssDNA) serves as a molecular bridge to conjugate MNPs with invertase (RC-MBI). Both systems operate via a cascade reaction: recombinase polymerase amplification (RPA) of target nucleic acids first activates Cas12a nuclease, which then exerts trans-cleavage activity toward the biosensing elements. Subsequent enzymatic hydrolysis generates glucose, whose concentration is quantifiable using a commercial personal glucose meter (PGM). All experimental procedures were conducted at a constant temperature of 37 °C, eliminating the need for complex thermal cycling equipment. Our findings demonstrate that the RC-HGPGA and RC-MBI platforms achieve ultra-sensitive detection of feline panleukopenia virus (FPV) and canine distemper virus (CDV)-two clinically significant pet viruses-with limits of detection (LODs) as low as 10° copies/μL and 101 copies/μL, respecti",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42648813/",
    "doi": "10.1016/j.aca.2026.345935",
    "pmid": "42648813",
    "authors": [
     "Mengqi Zhao",
     "Qianmin Zhuang",
     "Xiaowen Wang"
    ],
    "collected_by": "pubmed_alerts",
    "priority": 56
   },
   {
    "id": "pmid:42906597",
    "source": "PubMed",
    "journal": "American journal of veterinary research",
    "date": "2026-10-21",
    "title": "Advances in detection canine science at Auburn University.",
    "abstract": "",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42906597/",
    "doi": "10.2460/ajvr.26.10.0418",
    "pmid": "42906597",
    "authors": [
     "Emily Chester",
     "Lucia Lazarowski",
     "Xu Wang"
    ],
    "collected_by": "pubmed_core",
    "priority": 74
   },
   {
    "id": "pmid:42905671",
    "source": "PubMed",
    "journal": "PloS one",
    "date": "2026-01-01",
    "title": "A case study comparing the detection ability of cadaver detection dogs and electronic nose technology to a clandestine grave.",
    "abstract": "Cadaver detection dogs (CDDs) are one of the best tools to locate clandestinely buried human remains. However, large data gaps exist in what VOC classes and concentrations are targeted by CDDs for detection. This study compared the alert responses produced by CDDs used by the New South Wales Police Force to responses generated by an electronic nose (named the NOS.E) with metal oxide sensors to a clandestine burial. For confirmatory analysis, VOC samples of the clandestine burial were taken, and compounds were identified using GC × GC-TOFMS. While statistical work was limited due to sample sizes, inferences were made about VOC presence and concentration to NOS.E and detection dog ability. Both CDDs and NOS.E were able to detect targeted chemical classes (sulfur and nitrogen containing compounds, alcohols, alkanes and aldehydes) which was supported by GC × GC-TOFMS. Correlation analyses demonstrated non-significant, but observational patterns that CDDs true positive alerts were associated with higher NOS.E responses to sulfur and nitrogen containing compounds, alcohols and alkanes. Additionally, a \"no alert\" or \"False Positive\" alert was associated with lower NOS.E responses. This work supports that it is both the presence and abundance of VOC chemical classes that influence true positive alerts from CDDs to buried human remains.",
    "url": "https://pubmed.ncbi.nlm.nih.gov/42905671/",
    "doi": "10.1371/journal.pone.0360233",
    "pmid": "42905671",
    "authors": [
     "Amber O Brown",
     "Sandali Alahakone",
     "Erin Lamb"
    ],
    "collected_by": "pubmed_alerts",
    "priority": 50
   },
   {
    "id": "dvm360:https://www.dvm360.com/view/weekly-vet-report-thousands-of-veterinary-drugs-recalled-fda-drug-approval-more",
    "source": "dvm360",
    "journal": "dvm360",
    "date": "2026-10-24",
    "title": "Weekly Vet Report: Thousands of veterinary drugs recalled, FDA drug approval + more",
    "abstract": "A nationwide recall of thousands of compounded veterinary medication listings, the first New World screwworm detection in US wildlife since the parasite’s return, and a new FDA-approved antibiotic formulation for certain skin infections in dogs.",
    "url": "https://www.dvm360.com/view/weekly-vet-report-thousands-of-veterinary-drugs-recalled-fda-drug-approval-more",
    "doi": null,
    "pmid": null,
    "category_hint": "media_alert",
    "collected_by": "dvm360",
    "priority": 0
   },
   {
    "id": "gnews:https://news.google.com/rss/articles/CBMi8wFBVV95cUxOUVgwVmtLQXZFTTlLeEZONmpjVmhCSVZqNWNNV0ltRHhFYVVzSmNoSTlOYURXbTl4VUpKeWxtYWhSSzY4XzRKeFBxX3VldFctZ0NuUWllUjBYbWstb1ViY2tlZjFiWEJ",
    "source": "Google News",
    "journal": "Google News: new world screwworm dog",
    "date": "2026-10-23",
    "title": "How to protect your pets from the New World screwworm: Complete guide for dog and cat owners after Texas outbreak - Clarin.com",
    "abstract": "How to protect your pets from the New World screwworm: Complete guide for dog and cat owners after Texas outbreak&nbsp;&nbsp;Clarin.com",
    "url": "https://news.google.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?oc=5",
    "doi": null,
    "pmid": null,
    "category_hint": "media_alert",
    "collected_by": "gnews",
    "priority": 0
   },
   {
    "id": "gnews:https://news.google.com/rss/articles/CBMihgFBVV95cUxNYjdFSjdJbEx5MUF6ZUtfd2hzcTYwTkZCdU5QVlJzQ25lWTd1QnZXa3VaRzQyU014cHJIXzlCSjVwUEZ2cW5lOWRuN0lOdUkyWjNKckNrNkQ5XzY3S2QzS09QX0F6R29",
    "source": "Google News",
    "journal": "Google News: new world screwworm dog",
    "date": "2026-10-23",
    "title": "Screwworm in Texas: How to keep pets safe - FOX 4 News Dallas-Fort Worth",
    "abstract": "Screwworm in Texas: How to keep pets safe&nbsp;&nbsp;FOX 4 News Dallas-Fort Worth",
    "url": "https://news.google.com/rss/articles/CBMihgFBVV95cUxNYjdFSjdJbEx5MUF6ZUtfd2hzcTYwTkZCdU5QVlJzQ25lWTd1QnZXa3VaRzQyU014cHJIXzlCSjVwUEZ2cW5lOWRuN0lOdUkyWjNKckNrNkQ5XzY3S2QzS09QX0F6R29RMkhPaVNtcUg4RFBKX01tTHlmLTBHTk1iM19LRl9kQdIBiwFBVV95cUxNS1NVNmdmeEEyaFROYzk5UGhGQThsVThra1BnWkoxS3Y1UHJqSW94dWE1NnpEaDVJTlo1bTVvRE9ZanZMNlhEa3RNM29LQldLZUVnbUNPdEdjLVREM01PeVRvdFRoOUlVaWUwcDEwbnVIY2tIdThPcW10ZVFYWkJqOTFKVEZTUl9CM3dz?oc=5",
    "doi": null,
    "pmid": null,
    "category_hint": "media_alert",
    "collected_by": "gnews",
    "priority": 0
   },
   {
    "id": "gnews:https://news.google.com/rss/articles/CBMitAFBVV95cUxOS1dsaW9HbWhiOFFjcDlUdFNsTUFjYk1qWDV6RWpVZGJaamU3cElGbERJanVCNUhrZGJtY2c4MFI3Wm53a3Q5TjYxYzI5OTRjZ2VmZjE0YXRfTGFCakhUNjZGWG1Hc3R",
    "source": "Google News",
    "journal": "Google News: dog parvovirus outbreak",
    "date": "2026-10-22",
    "title": "Vet urges more pet owners to get dogs vaccinated amid virus outbreak - Kent Online",
    "abstract": "Vet urges more pet owners to get dogs vaccinated amid virus outbreak&nbsp;&nbsp;Kent Online",
    "url": "https://news.google.com/rss/articles/CBMitAFBVV95cUxOS1dsaW9HbWhiOFFjcDlUdFNsTUFjYk1qWDV6RWpVZGJaamU3cElGbERJanVCNUhrZGJtY2c4MFI3Wm53a3Q5TjYxYzI5OTRjZ2VmZjE0YXRfTGFCakhUNjZGWG1Hc3RTc3AzX0lPYmpSNDNXbEFOMGFNRUtjUlJCNHFNeHV2NUFpTzZUSXBZQk9zMm5YeGIzenRnM3FxR0hid1lvd3lCSjdVRkFZX2hSUTBPSlk?oc=5",
    "doi": null,
    "pmid": null,
    "category_hint": "media_alert",
    "collected_by": "gnews",
    "priority": 0
   },
   {
    "id": "dvm360:https://www.dvm360.com/view/higher-concentration-cefovecin-approved-by-fda-for-certain-skin-infections-in-dogs",
    "source": "dvm360",
    "journal": "dvm360",
    "date": "2026-10-21",
    "title": "Higher-concentration cefovecin approved by FDA for certain skin infections in dogs",
    "abstract": "A new version of an injectable antibiotic, first approved in 2008, is approved only for dogs, as 2 of its inactive ingredients may be toxic to cats.",
    "url": "https://www.dvm360.com/view/higher-concentration-cefovecin-approved-by-fda-for-certain-skin-infections-in-dogs",
    "doi": null,
    "pmid": null,
    "category_hint": "media_alert",
    "collected_by": "dvm360",
    "priority": 0
   },
   {
    "id": "gnews:https://news.google.com/rss/articles/CBMiZEFVX3lxTE1jWlU3aER6aExUaGViUkI5a09JZHE1VXV4UmhhWVRtUUJpblRWVXI3S0F2ZEdSMUJkOHB5b2ZLZ3lrdy05am1XQ3hVcVhkc0J3aGNscHBBdmhGbzJ3UWJ3WEk4d3Y?oc=",
    "source": "Google News",
    "journal": "Google News: H5N1 cat",
    "date": "2026-10-19",
    "title": "Cat Infectious Virus Alert - UExpress",
    "abstract": "Cat Infectious Virus Alert&nbsp;&nbsp;UExpress",
    "url": "https://news.google.com/rss/articles/CBMiZEFVX3lxTE1jWlU3aER6aExUaGViUkI5a09JZHE1VXV4UmhhWVRtUUJpblRWVXI3S0F2ZEdSMUJkOHB5b2ZLZ3lrdy05am1XQ3hVcVhkc0J3aGNscHBBdmhGbzJ3UWJ3WEk4d3Y?oc=5",
    "doi": null,
    "pmid": null,
    "category_hint": "media_alert",
    "collected_by": "gnews",
    "priority": 0
   },
   {
    "id": "gnews:https://news.google.com/rss/articles/CBMiogFBVV95cUxPcF9fTGEyZmM4c01WQmtHX2stTDRNSzdMOUtuUDV3ekRuelBPbHE0UXAxZUlrSGFUSmNZTjdDaXk2RTdwQWViQ0VvcTRzc0I2M0lvOVNYb3BidF9JUnBHX2U1MklHS3Z",
    "source": "Google News",
    "journal": "Google News: dog parvovirus outbreak",
    "date": "2026-10-19",
    "title": "Deadly feline disease outbreak kills 20 cats in Rivière-du-Loup, Que. - CBC",
    "abstract": "Deadly feline disease outbreak kills 20 cats in Rivière-du-Loup, Que.&nbsp;&nbsp;CBC",
    "url": "https://news.google.com/rss/articles/CBMiogFBVV95cUxPcF9fTGEyZmM4c01WQmtHX2stTDRNSzdMOUtuUDV3ekRuelBPbHE0UXAxZUlrSGFUSmNZTjdDaXk2RTdwQWViQ0VvcTRzc0I2M0lvOVNYb3BidF9JUnBHX2U1MklHS3ZhZEVYcXhwSXRhbEIybU9WdmFOYW9sMDlHQjVYc1VDeTlrTHdmQzhBTERzRThlVEpWMVNVTFFRMUNoZ0E?oc=5",
    "doi": null,
    "pmid": null,
    "category_hint": "media_alert",
    "collected_by": "gnews",
    "priority": 0
   },
   {
    "id": "dvm360:https://www.dvm360.com/view/dvm360-live-returns-with-a-doj-pet-food-lawsuit-screwworm-surveillance-and-more",
    "source": "dvm360",
    "journal": "dvm360",
    "date": "2026-10-16",
    "title": "dvm360 Live! returns with a DOJ pet food lawsuit, screwworm surveillance, and more",
    "abstract": "Adam Christman, DVM, MBA, returns as host for season 3, featuring a roundup of recent veterinary news and an appearance by guest Steve Mehler, DVM, DACVS.",
    "url": "https://www.dvm360.com/view/dvm360-live-returns-with-a-doj-pet-food-lawsuit-screwworm-surveillance-and-more",
    "doi": null,
    "pmid": null,
    "category_hint": "media_alert",
    "collected_by": "dvm360",
    "priority": 0
   }
  ]
 },
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  "gnews:screwworm New Mexico": {
   "ok": true,
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 }
}