# 小动物医学简报素材 · 2026-10-26

- 生成时间：2026-10-26 07:50（Asia/Shanghai）
- 检索窗口：2026-10-23 → 2026-10-26
- 条目数：临床研究 6 · 指南与监管 7 · 疾病预警 6
- 排序：临床研究按「期刊级别 + 时效」排序，越靠前越优先；指南监管与预警按日期倒序。

## 临床研究 Clinical Research（6 条）

1. **Systematic review supports the idea that no alternative test presently replaces elimination diet test and oral food challenge to diagnose canine adverse food reactions.**（Journal of the American Veterinary Medical Association · 2026-10-23）
   摘要：Adverse food reactions in dogs are clinically heterogeneous and overlap with canine atopic dermatitis, and diagnosis still relies on an elimination diet test followed by oral food challenge (EDT+OFC). Numerous allergen-specific tests have been proposed, but their diagnostic value remains controversial. Our objective was to identify, synthesize, and critically evaluate the diagnostic tests used or investigated for canine food allergy, with emphasis on their clinical validity, applicability, and a
   链接：https://pubmed.ncbi.nlm.nih.gov/42915224/
2. **Diagnosis of exocrine pancreatic insufficiency in dogs requires use of a newly adjusted reference range and diagnostic cutoff for measurement of trypsin-like immunoreactivity.**（Journal of the American Veterinary Medical Association · 2026-10-23）
   摘要：To adjust the reference interval (RI) for a commercially available canine trypsin-like immunoreactivity (cTLI) assay and the cutoff value for the diagnosis of exocrine pancreatic insufficiency (EPI). Lower limit of the RI was calculated based on the fifth percentile of cTLI concentrations in 102 clinically healthy dogs. Questionnaires were sent to clinicians for cases with serum cTLI concentrations ≤ 10 µg/L. Five board-certified small animal internists blinded to serum cTLI concentration indivi
   链接：https://pubmed.ncbi.nlm.nih.gov/42915069/
3. **Tablet crushing, but not splitting, alters the pharmacokinetics of extended-release levetiracetam in dogs.**（American journal of veterinary research · 2026-10-23）
   摘要：To compare the pharmacokinetics of intact, split, and crushed levetiracetam (LEV) extended-release (LEV-XR) tablets in dogs. We hypothesized that splitting produces a pharmacokinetic profile similar to intact tablets, whereas crushing results in earlier and higher maximum concentrations. Healthy research dogs were administered 500 mg LEV-XR orally as intact, split, or crushed tablets in a randomized crossover design. Plasma LEV concentrations were measured over 12 hours by high-pressure liquid c
   链接：https://pubmed.ncbi.nlm.nih.gov/42915569/
4. **Development and Validation of a New Online Tool for Monitoring Clinical Signs of Canine Atopic Dermatitis.**（Veterinary dermatology · 2026-10-23）
   摘要：The aim of the study was to develop a simple, reliable and validated patient-reported outcome tool for use in monitoring the severity of clinical signs in dogs with confirmed or suspected atopic allergies and recurrent otitis externa. The tool is called the Dog-Orientated Severity of Atopy Scale (DOSAS). The human Patient-Oriented Eczema Measure (POEM) was adapted for relevance to the owner-observable clinical signs of canine atopic dermatitis (cAD). Refinements were made via consultation with d
   链接：https://pubmed.ncbi.nlm.nih.gov/42925095/
5. **Retrospective Application of the Current International Myeloma Working Group Disease Definitions in 20 Cats With Immunoglobulin Secreting Neoplasms.**（Veterinary and comparative oncology · 2026-10-23）
   摘要：Studies describing feline myeloma related diseases (MRD) are limited and reported prognostic indicators are inconsistent. Cats more commonly exhibit visceral plasma cell tumours (PCTs) than marrow-predominant disease, suggesting that diagnostic approaches adapted from the International Myeloma Working Group (IMWG) criteria, incorporating extramedullary involvement and myeloma defining events (MDEs), may better capture clinically relevant disease. We sought to evaluate cats with serum protein ele
   链接：https://pubmed.ncbi.nlm.nih.gov/42918624/
6. **Co-occurrence of blaNDM-5 and mcr-1 on Two Distinct, Independently Transferable Plasmids in Commensal Escherichia coli ST156 from a Healthy Companion Dog.**（Microbial drug resistance (Larchmont, N.Y.) · 2026-10-23）
   摘要：The emergence of carbapenem- and colistin-resistant Enterobacterales mediated by transmissible plasmids poses a critical One Health threat by compromising the efficacy of last-resort antimicrobials. We characterized a commensal Escherichia coli ST156 isolate recovered from a clinically healthy companion dog in South Korea that carried blaNDM-5 and mcr-1 on distinct plasmids. Antimicrobial susceptibility testing revealed a multidrug-resistant phenotype, including resistance to carbapenems (imipen
   链接：https://pubmed.ncbi.nlm.nih.gov/42924521/

## 指南与监管 Guidelines & Regulation（7 条）

1. **Issuance of Priority Review Voucher; Rare Pediatric Disease Product; ISEMBYLD (apitegromab-mstn)**（Federal Register (Notice) · 2026-10-26）
   摘要：The Food and Drug Administration (FDA) is announcing the issuance of a priority review voucher to the sponsor of a rare pediatric disease product application. The Federal Food, Drug, and Cosmetic Act (FD&C Act) authorizes FDA to award priority review vouchers to sponsors of approved rare pediatric disease product applications that meet certain criteria. FDA is required to publish notice of the award of the priority review voucher. FDA has determined that ISEMBYLD (apitegromab-mstn), approved Sep
   链接：https://www.federalregister.gov/documents/2026/10/26/2026-21718/issuance-of-priority-review-voucher-rare-pediatric-disease-product-isembyld-apitegromab-mstn
2. **A large-scale consensus study of a diagnostic algorithm for canine and feline mammary tumor histopathology: An attempt to improve inter-observer agreement.**（Veterinary pathology · 2026-10-25）
   摘要：Histological classification of mammary proliferative lesions in dogs and cats is essential for prognostic and predictive studies, as well as for comparative oncology; however, standardization of diagnoses is highly affected by substantial interobserver variability. In this study, a structured diagnostic algorithm based on the Davis-Thompson Foundation classification was assessed for the ability to improve interobserver agreement in the morphological diagnoses of mammary gland lesions in dogs and
   链接：https://pubmed.ncbi.nlm.nih.gov/42927477/
3. **Agency Information Collection Activities; Proposed Collection; Comment Request; Export Certificates for FDA Regulated Products**（Federal Register (Notice) · 2026-10-23）
   摘要：The Food and Drug Administration (FDA or Agency) is announcing an opportunity for public comment on the proposed collection of certain information by the Agency. Under the Paperwork Reduction Act of 1995 (PRA), Federal Agencies are required to publish notice in the Federal Register concerning each proposed collection of information, including each proposed extension of an existing collection of information, and to allow 60 days for public comment in response to the notice. This notice solicits c
   链接：https://www.federalregister.gov/documents/2026/10/23/2026-21714/agency-information-collection-activities-proposed-collection-comment-request-export-certificates-for
4. **Regulatory Considerations for Prescription Drug Use-Related Software; Guidance for Industry; Availability**（Federal Register (Notice) · 2026-10-21）
   摘要：The Food and Drug Administration (FDA or Agency) is announcing the availability of a final guidance for industry titled "Regulatory Considerations for Prescription Drug Use-Related Software." This final guidance describes FDA's application of its drug labeling authorities to certain software outputs that are disseminated by or on behalf of a drug sponsor for use with a prescription drug product or a prescription drug-led, drug-device combination product that is assigned to the Center for Drug Ev
   链接：https://www.federalregister.gov/documents/2026/10/21/2026-21516/regulatory-considerations-for-prescription-drug-use-related-software-guidance-for-industry
5. **New Dietary Ingredient (NDI) Notifications and Related Issues; Identity and Safety Information About the NDI: Guidance for Industry; Availability**（Federal Register (Notice) · 2026-10-20）
   摘要：The Food and Drug Administration (FDA or we) is announcing the availability of a final guidance for industry entitled "New Dietary Ingredient (NDI) Notifications and Related Issues; Identity and Safety Information About the NDI: Guidance for Industry." The guidance focuses on frequently asked questions about the new dietary ingredient notification (NDIN) submissions. This guidance is intended to help provide recommendations to manufacturers and distributors of NDIs and dietary supplements contai
   链接：https://www.federalregister.gov/documents/2026/10/20/2026-21453/new-dietary-ingredient-ndi-notifications-and-related-issues-identity-and-safety-information-about
6. **Advancing Dental Care Worldwide: Our Updated Global Dental Guidelines Are Here**（WSAVA · 2026-09-24）
   摘要：Our updated 2026 Global Dental Guidelines are now available, providing veterinary professionals worldwide with practical, evidence-based guidance to support the prevention, diagnosis and treatment of oral and dental disease in companion animals.
   链接：https://wsava.org/updates/advancing-dental-care-worldwide-our-updated-global-dental-guidelines-are-here/
7. **Update on the Working Group following Erratum Published in March 2025**（WSAVA · 2026-08-29）
   摘要：WSAVA has published an update on the Multidisciplinary Reproduction Control Working Group following the Erratum published in March 2025.
   链接：https://wsava.org/updates/update-on-the-working-group-following-erratum-published-in-march-2025/

## 疾病预警 Disease Alerts（6 条）

1. **Weekly Vet Report: Thousands of veterinary drugs recalled, FDA drug approval + more**（dvm360 · 2026-10-24）
   摘要：A nationwide recall of thousands of compounded veterinary medication listings, the first New World screwworm detection in US wildlife since the parasite’s return, and a new FDA-approved antibiotic formulation for certain skin infections in dogs.
   链接：https://www.dvm360.com/view/weekly-vet-report-thousands-of-veterinary-drugs-recalled-fda-drug-approval-more
2. **How to protect your pets from the New World screwworm: Complete guide for dog and cat owners after Texas outbreak - Clarin.com**（Google News: new world screwworm dog · 2026-10-23）
   摘要：How to protect your pets from the New World screwworm: Complete guide for dog and cat owners after Texas outbreak  Clarin.com
   链接：https://news.google.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?oc=5
3. **Screwworm in Texas: How to keep pets safe - FOX 4 News Dallas-Fort Worth**（Google News: new world screwworm dog · 2026-10-23）
   摘要：Screwworm in Texas: How to keep pets safe  FOX 4 News Dallas-Fort Worth
   链接：https://news.google.com/rss/articles/CBMihgFBVV95cUxNYjdFSjdJbEx5MUF6ZUtfd2hzcTYwTkZCdU5QVlJzQ25lWTd1QnZXa3VaRzQyU014cHJIXzlCSjVwUEZ2cW5lOWRuN0lOdUkyWjNKckNrNkQ5XzY3S2QzS09QX0F6R29RMkhPaVNtcUg4RFBKX01tTHlmLTBHTk1iM19LRl9kQdIBiwFBVV95cUxNS1NVNmdmeEEyaFROYzk5UGhGQThsVThra1BnWkoxS3Y1UHJqSW94dWE1NnpEaDVJTlo1bTVvRE9ZanZMNlhEa3RNM29LQldLZUVnbUNPdEdjLVREM01PeVRvdFRoOUlVaWUwcDEwbnVIY2tIdThPcW10ZVFYWkJqOTFKVEZTUl9CM3dz?oc=5
4. **Vet urges more pet owners to get dogs vaccinated amid virus outbreak - Kent Online**（Google News: dog parvovirus outbreak · 2026-10-22）
   摘要：Vet urges more pet owners to get dogs vaccinated amid virus outbreak  Kent Online
   链接：https://news.google.com/rss/articles/CBMitAFBVV95cUxOS1dsaW9HbWhiOFFjcDlUdFNsTUFjYk1qWDV6RWpVZGJaamU3cElGbERJanVCNUhrZGJtY2c4MFI3Wm53a3Q5TjYxYzI5OTRjZ2VmZjE0YXRfTGFCakhUNjZGWG1Hc3RTc3AzX0lPYmpSNDNXbEFOMGFNRUtjUlJCNHFNeHV2NUFpTzZUSXBZQk9zMm5YeGIzenRnM3FxR0hid1lvd3lCSjdVRkFZX2hSUTBPSlk?oc=5
5. **Higher-concentration cefovecin approved by FDA for certain skin infections in dogs**（dvm360 · 2026-10-21）
   摘要：A new version of an injectable antibiotic, first approved in 2008, is approved only for dogs, as 2 of its inactive ingredients may be toxic to cats.
   链接：https://www.dvm360.com/view/higher-concentration-cefovecin-approved-by-fda-for-certain-skin-infections-in-dogs
6. **dvm360 Live! returns with a DOJ pet food lawsuit, screwworm surveillance, and more**（dvm360 · 2026-10-16）
   摘要：Adam Christman, DVM, MBA, returns as host for season 3, featuring a roundup of recent veterinary news and an appearance by guest Steve Mehler, DVM, DACVS.
   链接：https://www.dvm360.com/view/dvm360-live-returns-with-a-doj-pet-food-lawsuit-screwworm-surveillance-and-more